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The activation of ALT can lead to suppression of telomerase activity (OSullivan et al 2014) hence, we observed no increase in telomerase enzyme activity in the cancer cells after treatment with epitalon

The mean plasma concentration-time profiles of ASD (M0), M3, M4 and M5 in different groups are presented in Figures 4, 5, and the corresponding pharmacokinetic parameters calculated by non-compartmental analysis are summarized in Table 3