LMNA R349W pathogenic variant (exon 6) is associated with facial fat loss which is uncommon in FPLD2 (104, 108, 109)
Individuals with certain genetic profiles may experience greater bioavailability or therapeutic benefit, while others show minimal change in intracellular glutathione despite oral or IV administration
In an extension for participants who started with a BMI of at least 35, the average reached 30.3% at 104 weeks
How do the potential benefits of improved metabolic health balance against any theoretical cancer-related concerns
A similar conversation is now emerging around obesity medicines: GLP-1 and dual agonists are being recognised internationally as evidence-based treatments for obesity with cardiometabolic benefit.[8] Indian insurers may progressively consider coverage when obesity is severe and linked with diabetes, heart disease, or sleep apnoea, rather than for cosmetic weight loss alone.[10] For families, this could mean negotiating group policies and reading the policy wording carefully to see if medically supervised GLP-1 therapy for obesity-with-complications is covered