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While the exact mechanisms leading to NASH are still unclear, the prevalence of obese patients diagnosed with NASH strongly suggests lack of blood sugar control, insulin resistance, and blood lipid problems may play a significant role (2)

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Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)