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They may ameliorate OS by controlling the production of ROS, improving mitochondrial dysfunction of cells, scavenge free radicals, or enhance antioxidant defense enzymes and their related pathways, such as Nrf2 pathway, oxygenase-1 (HO-1) pathway, Kelch-like ECH-associated protein 1 (Keap1) pathway, and antioxidant response elements (ARE) pathway to improve OS-induced insulin resistance (Nishikawa et al., 2000

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El glutatin es un tripptido y est formado por los aminocidos cistena, glicina y el cido glutmico

Despite the high level of reduced GSH, a small change in the ratio between the reduced and the oxidized GSH form (GSH:GSSG) can substantially affect E GSH , thus impairing cellular redox balance 17

PRCC quantifies the influence of a model input on the output of interest thus revealing the input factors that drive the largest changes in the level of the outcome of interest