doi: 10.1289/ehp.7688
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomized, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
Clinical studies have revealed that PCOS patients exhibit significantly reduced gut fungal diversity and altered community structure, characterized by an increase in Ascomycota and a decrease in Basidiomycota, alongside notable enrichment of pathogenic fungi such as Candida and Malassezia (68)
Enzymolysis, which uses enzymes to hydrolyze cell walls and release polysaccharides, offers high efficiency and gentle conditions but is limited by the high cost of enzymes
This guide aggregates the available rodent PK data, protocol-design implications, and known gaps