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Histamine Intolerance and MCAS Flares: Sulforaphane acts directly on mast cell signaling pathways (like caspase-1) to inhibit degranulation, reducing the systemic release of histamine that causes hives, flushing, tachycardia, and gastrointestinal distress

Fielding CJ, Fielding PE

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In one specific embodiment of the auris-acceptable controlled-release formulations described herein, the active agent is provided in a gel matrix, also referred to herein as auris-acceptable gel formulations, auris interna-acceptable gel formulations, auris media-acceptable gel formulations, auris externa-acceptable gel formulations, auris gel formulations, or variations thereof

During the first phase, the oxidation of the active site selenol (Se-H) to selenenic acid (Se-OH) pf the GPX4 leads to the reduction of the toxic lipid peroxides to generate the non-toxic lipid alcohols (Figure 4)