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The Rise of GLP-1 Drugs Because of the hormones powerful effects on appetite and glucose metabolism, researchers began exploring whether GLP-1 drugs could replicate or amplify these natural signals

This dose can be held for up to four weeks before reattempting an increase

Critically, the glucagon component appeared to drive increased energy expenditure and enhanced hepatic lipid oxidation without negating the glucose-lowering benefits conferred by GLP-1 and GIP activity

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While this study showed a positive impact on sleep parameters, such as decreases in early wake time and percentage of N2 sleep, there was no effect of melatonin on a circadian marker, sleep onset latency [17]