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Tirzepatide has already completed this journey twice, earning approval for type 2 diabetes (Mounjaro, 2022) and chronic weight management (Zepbound, 2023)

These smaller molecules can independently suppress appetite and are associated with lower body weight and improved glucose regulation

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Proc Natl Acad Sci USA 85:35853589 Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL et al (2002) Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

The primary enzymes responsible for this transformation in the human body are CAT and GSH-Px