Cells were cultured at 37 C in Dulbeccos modified Eagles medium (DMEM) + GlutaMax 1965 (Gibco) supplemented with 10% fetal bovine serum and 1% penicillinstreptomycin in a humidified 10% CO 2 incubator
352 Elacestrant has emerged as the first FDA-approved oral estrogen receptor antagonist for ESR1 -mutant patients, owing to substantial improvements in progression-free survival (PFS) observed during the EMERALD phase 3 trial in the ESR1 -mutant population
Taurine is involved in energy metabolism in muscles, adipose tissue, and the liver
Sabate M, Ibanez L, Perez E, Vidal X, Buti M, Xiiol X, Mas A, Guarner C, Forne M, Sola R, Castellote J, Rigau J, Laporte JR: Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a propective case series
We defined S to be a factor multiplying the V max values of GCL and GPX representing the activation of GCL and GPX, so S = 1 for males and S = 1.8 for females for average estradiol, since we make a case based on experimental and clinical results that the activation is by 80%