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Abbreviations ALS: amyotrophic lateral sclerosis ALSFRS-R: Revised ALS Functional Rating Scale CNS: central nervous system CSF: cerebrospinal fluid FALS: familial amyotrophic lateral sclerosis GM-CSF: granulocyte-macrophage colony-stimulating factor GSH: glutathione IFN: interferon Ig: immunoglobulin IL: interleukin MCP-1: monocyte chemoattractant protein-1 NO: nitric oxide PCA: perchloric acid ROS: reactive oxygen species RT: room temperature SALS: sporadic amyotrophic lateral sclerosis SOD1: Cu/Zn superoxide dismutase TNF-: tumor necrosis factor-alpha VEGF: vascular endothelial growth factor References Tandan R, Bradley WG

Tear deficiency, impaired or abnormal mucus production