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approximately 15-30% of patients) Diarrhea (13-24%) Vomiting (6-12%) Constipation (6-17%) Abdominal pain (6-10%) Dyspepsia (6-9%) Decreased appetite (5-10%) These gastrointestinal effects are typically most pronounced during dose escalation and tend to diminish over time as the body adjusts to the medication

Not recommended for children or pregnant women

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The orobuccal route, however, is very effective and glutathione is rapidly absorbed directly into systemic circulation with rapid rise in serum concentration, as we shall see in the following sections

N-Acetylcysteine (NAC) Directly supplies cysteine, essential for glutathione synthesis