In animal models, use of the choline TMA lyase inhibitor iodomethyl choline (IMC) increases bacterial cholesterol metabolite loss and decreases intestinal sterol transport protein Niemann-Pick C1-Like 1 (NPC1L1) expression, reshaping gut microbiota and reducing hepatic cholesterol accumulation, while upregulating CYP7A1 and other bile acid-related genes (Pathak et al., 2020)
Maintaining a consistent rotation schedulesuch as injecting into four different quadrants of your abdomendistributes the inflammatory burden and reduces cumulative irritation
However, several clinical situations, including insulin-resistant states, PCOS, gestational diabetes, and advanced maternal age, have been associated with reduced tissue myo-inositol concentrations or increased urinary loss, as documented in multiple studies between 2019 and 2024
Take this medication under the guidance of your health advisor
Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism