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Wegovy (semaglutide) activates one receptor (GLP-1), while Zepbound (tirzepatide) activates two (GIP and GLP-1)

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In an APP/PS1 model of AD, D-Ala2-GIP reduced activation of chronic inflammatory response in the brain, oxidative stress, synapse loss, amyloid plaque burden, and DNA damage [106]

The studys strengths include its substantial sample size, diverse international patient population, and real-world clinical setting, which enhance the generalizability of our findings

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