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Nevertheless, unimolecular GIPGLP-1 co-agonism is an effective therapy for type 2 diabetes, associated with weight loss and reduction of fat mass, in rats, mice, monkeys and humans [66]
Moreover, ECM-induced architectural remodeling may impair hepatic insulin clearance, a process that normally extracts approximately 50% of circulating insulin during the livers first pass (148, 149)
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