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Erythrocyte NAD(H) levels started to saturate already with 500-750 mg of niacin and increasing the dose up to 1000 mg had only a slight additional effect on steady-state NAD + in blood cells

This fear not only worsens psychological distress but also hampers effective self-management, creating a vicious cycle that leads to a decline in mental health

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And those using it believe they are doing their own research. The standard response from the wellness industry is that the absence of evidence is not evidence of absence that these compounds simply havent been studied yet