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Cardiovascular Risk Targets Tighten Further For patients at high cardiovascular or kidney risk, the guidelines now encourage: Systolic blood pressure targets below 120 mmHg when safe More precise titration of antihypertensive therapy Stronger emphasis on ACE inhibitors or ARBs in albuminuric kidney disease They also reinforce what not to add

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PGE-2 increases vasodilatation and thereby induces pain