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This suggests the two medication classes operate independently in most patients

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In May 2026, Phase 3 topline results from the TRIUMPH-1 trial across 2,339 participants showed an average 28.3 percent body weight reduction over 80 weeks at the highest dose, with 45.3 percent of those participants losing at least 30 percent of body weight a threshold previously achievable only through surgery

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Approval is expected in 2027, pending successful completion of Phase 3 trials