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DREAMS-3 enrolled 349 adults with type 2 diabetes and obesity who had not achieved adequate weight or blood sugar control with lifestyle changes alone

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The medications work through complementary mechanisms to improve overall glucose control

In a rodent twobottlechoice paradigm, pretreatment with exenatide administered systemically [51, 52, 56], or injected centrally into the VTA [52, 57], NTS [53], NAc, dorsal hippocampus, lateral hypothalamus [57], NAc shell [54, 57] or laterodorsal tegmental area [54], is reported to reduce alcohol intake

PAR2 flox [ B6(Cg)-F2rl1 tm3.1Wmrf /Tarc ] were used as wild-type controls (PAR2-WT)