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Pro-inflammatory cytokines stimulate corticotropin-releasing hormone (CRH) secretion and impair glucocorticoid receptor signaling, resulting in diminished negative feedback and sustained hypercortisolemia

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It has also regulated tryptophanserotonin metabolism, modulated the HPA axis and shifted inflammatory markers (reduced IL-6, IFN- and increased IL-10), supporting the effect of probiotic on reducing anxiety-like behavior via MGBA regulation (Jia et al., 2024)

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It is important to highlight that the only legal path runs through licensed pharmacies, valid prescriptions, and FDA-permitted compounds