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The reduction in both the diversity and abundance of gut microbiota compromises microbial defense mechanisms, facilitating pathogenic bacteria invasion of the intestinal mucosa, breaching the intestinal barrier, and triggering immune dysregulation that promotes the development of colitis[72], [73]

Using a L-5-methyltetrahydrofolate instead of folic acid, and ensuring we have optimal B12 in the form of methylcobalamin, and vitamin B6 in P-5-P form are key in helping with these pathways

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