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Key advantages: Oral administration (no injection burden) Scalable manufacturing Potential for combination therapies Broader patient adherence However, these molecules also reintroduce important questions: Will small-molecule receptor activation alter tissue selectivity

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3) or overexpression of ARL8 16,17,21,42 causes the peripheral dispersion of lysosomes, while conversely, the overexpression of TBC1D9B leads to perinuclear clustering of lysosomes similar to the loss of ARL8B 16,21 (compare Fig