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The extract also induced significant vasorelaxation in isolated rat aorta, depending on the synthesis or release of endothelium-derived relaxing factors (EDRFs), the activation of prostanoid receptors (PGI 2 and PGE 2 ), blocking VDCCs, and, to a lesser degree, ROCCs (461)

In individuals with irritable bowel syndrome, chrons disease, and ulcerative colitis, intravenous and intramuscular routes may be preferred

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