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Materials and methods Animals and experimental procedure This study was carried out at the Sakarya University Faculty of Medicines Experimental Animal Centre following approval from the Sakarya University Animal Experiments Local Ethics Committee

p = 0.006) and favorable scores on the Montgomery-sberg Depression Rating Scale (MADRS), persisting 12 months post-treatment, suggesting possible disease-modifying effects [54, 55]

These results indicate that diabetes-induced downregulated connexin-43 expression involves in promoting retinal vascular impairment linked to diabetic retinopathy