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Recent studies have reported the development of new chemical scaffolds as NAPRT inhibitors, demonstrating comparable anti-cancer activity to 2-OHNA with improved solubility and favorable drug-like profiles

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Invest Dermatol Apr 135 (4), 10801088

In hypothalamic pro-opiomelanocortin (POMC) neurons, knockdown of family with sequence similarity 172 member A (Fam172a) stimulates glycolysis and increases the levels of peptidylglycine -amidating monooxygenase (PAM), which affects the synthesis of -melanocyte-stimulating hormone (-MSH) via H4K12la, eventually exerting an anti-obesity effect