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These complement peptide mechanisms without interfering with them

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Lipoprotein (a) is a recognised independent cardiovascular risk factor, mainly of ischaemic heart disease/myocardial infarction and aortic valve stenosis [45]

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases