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The following formula illustrates how CMS would calculate the benchmark period manufacturer price for a Part D rebatable drug with a payment amount benchmark period identified under proposed 428.202(c)(1), as proposed in 428.202(d)(1): (AMP for calendar quarter beginning January 2021) multiplied by (sum of monthly AMP units for January 2021 calendar quarter divided by sum of the units reported for the 3 quarters of the payment amount benchmark period) + (AMP for calendar quarter beginning April 2021) multiplied by (sum of monthly AMP units for April 2021 calendar quarter divided by sum of the units reported for the 3 quarters of the payment amount benchmark period) + (AMP for calendar quarter beginning July 2021) multiplied by (sum of monthly AMP units for July 2021 calendar quarter divided by sum of the units reported for the 3 quarters of the payment amount benchmark period) For a Part D rebatable drug with a payment amount benchmark period identified under proposed 428.202(c)(2) through (5), the following formula illustrates how CMS would calculate the benchmark period manufacturer price for a Part D rebatable drug as proposed in 428.202(d)(2): (AMP for calendar quarter beginning January) multiplied by (sum of monthly AMP units for January calendar quarter divided by sum of the monthly units reported for the 4 quarters of the payment amount benchmark period) + (AMP for calendar quarter beginning April) multiplied by (sum of monthly AMP units for April calendar quarter divided by sum of the monthly units reported for the 4 quarters of the payment amount benchmark period) + (AMP for calendar quarter beginning July) multiplied by (sum of monthly AMP units for July calendar quarter divided by sum of the monthly units reported for the 4 quarters of the payment amount benchmark period) + (AMP for calendar quarter beginning October) multiplied by (sum of monthly AMP units for October calendar quarter divided by sum of the monthly units reported for the 4 quarters of the payment amount benchmark period) (4) Identification of the Benchmark Period CPI-U To calculate the inflation-adjusted payment amount in accordance with section 1860D-14B(b)(3), CMS must identify the benchmark period CPI-U

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Advancing Policies to Strengthen Cancer Prevention and Screening Programs Nearly 40 percent of cancer cases in the United States can be attributed to preventable risk factors, such as tobacco use, dietary factors, and ultraviolet (UV) exposure (see Reducing the Risk of Cancer Development )

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