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Justification for use of FL83B mouse hepatocytes and mouse C2C12 myoblasts Liver is a major player in the synthesis and secretion of VDBP and the hydroxylation of cholecalciferol (vitamin D 3 ) to 25-hydroxy-vitamin D

Moreover, MEK/ERK signal pathway activated by insulin, which can also be triggered by KRAS mutation, plays an essential role in PDA malignancy and invasion (Wang et al., 2019)

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It is currently under regulatory review and is not yet approved for use