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Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks

In experimental biological matrices, this degradation limits the effective exposure window and complicates dose-response characterization

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LDL-C and TC mediate the risk of PNPLA3 inhibition in cardiovascular diseases