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Additionally, thrombotic events specifically DVT (0.8% vs 0.2%), PE (0.5% vs 0.2%), and superficial phlebitis (0.4% vs 0%) occurred more often in women with axillary node-negative, estrogen-receptor positive breast cancer who received adjuvant tamoxifen (n = 1422) compared with placebo (n = 1437) following primary surgery in a randomized, double-blind study (the NSABP B-14 study)

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