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This would otherwise be not possible without using the proposed methods (or using single traditional marker)

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Moreover, another distressing symptom in CKD and ESRD is pruritus (CKD-aP), which further reduces QoL [6]

He named hyaluronic acid as the top choice because its a naturally occurring substance within the skin and soft tissues, so theres really no meaningful risk of rejection or reaction and, crucially, its reversible. Other options include laser resurfacing, ultrasound devices and in the most extreme cases going under the knife