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Ca(2+)/calmodulin-mediated desensitization of glutamate receptors shapes plant systemic wound signalling and anti-herbivore defence

Suppression of Rac1 activity either by intragastric application of Rac1 inhibitor, Ehop-016, or by expression of dominant negative Rac1 rescued memory loss of APP/PS1 mice in water maze test, suggesting that increased Rac1 activity was responsible for the memory loss (Wu et al., 2019)

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However, the failure of many antioxidant clinical studies suggests that a sound mechanistic approach is ultimately needed to improve the design of future studies