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Although CD47 is ubiquitously expressed on healthy cells, it is frequently overexpressed in both hematologic malignancies and solid tumors, where it interacts with signal regulatory protein alpha (SIRP) expressed on macrophages and dendritic cells ( Owing to its upstream position in immune regulation, CD47 has emerged as a promising therapeutic target with the potential to link innate and adaptive immune responses, particularly in immunologically cold tumors that exhibit limited T cell infiltration and poor responsiveness to PD-1/PDL1-directed therapies ( Nevertheless, the CD47-SIRP axis remains a compelling target in cancer immunotherapy

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His widow later sued Philip Morris, contending that McLean had to smoke pack after pack of cigarettes during Marlboro shoots so directors could create the perfect scene