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Folate-targeted nanoparticles for glutamine metabolism Inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer

For improved production of N -acetylglucosamine, the authors engineered a conditional addiction circuit using a suicide gene FCY1 regulated by glmS ribozyme that degrades its transcripts when triggered by a high level of the product intermediate [22]

Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis

Changes in gene expression levels of glutamate-cysteine ligase (GCL), glutathione peroxidase (GPx1), glutathione reductase (GR) and glutathione synthetase (GS) genes were analyzed by real-time qPCR on ABI PRISM 7500 (Applied Biosystems)

Lee DH, Jacobs DR