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Additionally, diabetes mellitus has been linked to increased formation of free radicals and a reduction in antioxidant activities, which also results in the imbalance between the generation of ROS and antioxidants, thus leading to oxidative damage to cell proteins, lipids, and nucleic acids

(2005) Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase

When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment

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Glutathione works by helping neutralise these molecules and supporting the bodys natural detoxification processes