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Ipamorelin binds with ghrelin receptors in the brain, triggering several physiological effects, which include stimulation of the pituitary gland to release GH

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A transcriptome analysis of DIO mice treated with the 2 GLP-1RAs for 7 days (BW loss ~18%) showed similar upregulation of TH in the AP, with no differences in the ARH (data not shown)