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Rational dose selection and proper use of opioid drugs, through knowledge of their mechanisms of action, allow avoiding side effects related to their use

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Bcl-2 is posited as an anti-apoptotic protein that apparently inhibits cell death, while Bax is suggested to be a pro-apoptotic protein that promotes cell death

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They suppress appetite through different neurological mechanisms, covering more ground than either pathway can cover alone

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DOI: 10.1371/journal.pone.0088063

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