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According to a study by the Centers for Disease Control and Prevention (CDC) titled Alcohol Poisoning Deaths: United States, 20102012, published in the Morbidity and Mortality Weekly Report (2015), approximately 2,221 deaths occur annually in the U.S

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In terms of potential antitumor activity, -glutamyl-protected N -hydroxyguanidines (NHGs) have been developed to explore the ability to deliver NO to the kidney ( Figure 5A )