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VP13 Estimating Meaningful Score Differences and Meaningful Score Regions for the PROMIS Pediatric Asthma Impact Scale Jing Yuan 1 , Li Lin 2 , Kevin Weinfurt 2 , Nicole Lucas 2 , Allison Burbank 3 , Michelle Hernandez 3 , I-Chan Huang 4 , Bryce Reeve 1 1 Duke University, Durham, North Carolina, USA, 2 Duke University School of Medicine, Durham, North Carolina, USA, 3 University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

NICE guidance suggests trying probiotics for at least four weeks whilst monitoring symptom improvement