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In severe influenza infections, viruses migrate from the upper respiratory tract to the lower respiratory tract, where infection of the lower lung epithelia triggers inflammatory cell recruitment, causing damage to the alveolar epithelial cells responsible for gas exchange in the lungs
Greater weight was given to longitudinal studies, systematic reviews, large population-based surveys, and well-controlled experimental or mechanistic studies, while evidence from cross-sectional or self-reported data was interpreted with caution
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The research, which was commissioned by the UK Department for Health and Social Care, includes mortality data on men from the British Doctors Study and data on women from the Million Women Study, a news release says
