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When these vesicles enter the CNS, they activate microglia and astrocytes through TLR signaling, resulting in local cytokine production and neuroinflammatory cascades

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J Inherit Metab Dis 26(23):181188 Wang IC, Sugai JV, Majzoub J, Johnston J, Giannobile WV, Wang HL (2022) Pro-inflammatory profiles in cardiovascular disease patients with peri-implantitis