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Peripheral inflammatory signals can access the central nervous system through humoral, neural, and cellular pathways, including cytokine transport across the bloodbrain barrier and vagal nerve signaling, thereby initiating or amplifying central immune activation (31)

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Another network meta-analysis of RCTs, including participants with T2DM, found that GLP-1 RAs decreased the risk of non-fatal MI (Odds Ratio [OR] = 0.92, 95%CI = 0.850.99) when compared to placebo or standard care (Palmer et al., 2021)

Exclusion criteria were current smoking habit or use of nutritional supplements, and any problems that might affect their ability to perform resistance training

By improving gut health, increasing microbial diversity, and boosting SCFA production, we can help the body make and respond to GLP-1 in a more natural way