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109 Additionally, metabolites such as 2-hydroxyglutarate, succinate, and fumarate derived from mutations in IDH1/2, FH, and SDH inhibit DNA repair pathways by repressing lysine demethylase KDM4B, resulting in abnormal excessive H3K9 methylation at DNA break sites, impairing recruitment of TIP60 and ATM, reducing end resection, and decreasing recruitment of downstream repair factors

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