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Importantly, sustained cortisol elevation can suppress the HPT axis by inhibiting TRH expression, reducing TSH secretion, and impairing deiodinase activity, which not only blunts thyroid hormone production but may also raise rT3 levels and exacerbate functional hypothyroidism in susceptible individuals

So I think employers are increasingly desperate to find ways we can actually control the spend, Putnoky said

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428 Furthermore, secondary senescence can occur due to inflammatory and fibrotic factors such as CCL2, IL-1b, IL-6, IL-8, and TGF-