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Common Symptoms of Hypothyroidism fatigue or lack of energy weight gain and/or difficulty losing weight weakness dry, coarse hair hair loss dry skin cold intolerance, cold extremities muscle cramps frequent muscle aches constipation depression irritability memory loss abnormal menstrual cycles decreased libido Most people have varying combinations and severity levels of these symptoms

During stress or injury, it has been suggested that muscles produce an alternative peptide called IGF-IEc, which contains extra "exons" or domains

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Some focus on small-scale microscopic details, while others examine larger-scale tissue healing

Its role appears modulatory rather than suppressive, supporting coordinated neural and endocrine timing rather than inducing forced sleep states