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doi: 10.1016/j.pbi.2015.04.006 17 ChiangF.MazdiyasniO.AghaKouchakA

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4.3 Consequences of mtDNA damage: from bioenergetic crisis to immune exhaustion mtDNA mutations and depletion impair the synthesis of essential ETC components, resulting in defective OXPHOS, reduced ATP synthesis, collapse of the mitochondrial membrane potential (m), and accumulation of metabolic intermediates due to TCA cycle disruption and compensatory glycolysis

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Those who have experienced these injuries claim that pharmaceutical companies Novo Nordisk and Eli Lilly failed to warn patients of the adverse side effects from Ozempic (semaglutide)