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Under conditions of oxidative stress, Keap1-CUL3-E3 ubiquitin ligase undergoes conformational changes that disrupt the binding of Nrf2 to Keap1

Bulletin of Experimental Biology and Medicine, 167 (5), 641-644

By reducing cortisol and indirectly supporting hormonal balance, DSIP promotes a favorable hormonal environment for muscle building and fat loss

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Testosterone may be aromatized to estradiol in adipocytes and a negative feedback loop wherein exogenously administered testosterone results in decreased spermatogenesis via inhibition of follicle-stimulating hormone (FSH) and LH can occur