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Researchers may explore this in relevant models

It has been suggested that a combination of genetic factors [e.g., variation at human leukocyte antigen (HLA) loci], environmental exposures (e.g., smoking), and the microbiota contribute to the development of RA (Smolen et al., 2018)

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Given that various chemical substances have been identified as neurotransmitters/neuromodulators in mammals, eliciting long-distance ionic responses that effectively mediate neurotransmission, identification of more systematic signaling molecules in the future would offer new insights into the complex systemic defense signaling in plants