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Premature whitening or graying of hair on the scalp, eyebrows, eyelashes, or beard

Payer policies increasingly require evidence of conservative management attempts before approving more invasive interventions

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Targeting: It offers a more targeted approach to metabolic dysfunction, often improving blood sugar and cardiovascular markers alongside weight loss

When paired with liquid biopsy monitoring, these designs enable real-time therapeutic redirection, exemplified by ctDNA guided switching to osimertinib upon emergence of EGFR T790M mutations in NSCLC (214) Platform trials such as NCI-MATCH and GBM AGILE maintain perpetual infrastructures optimized for testing combination and sequencing strategies in highly heterogeneous tumors (215, 216)