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In a study[1], nicotine changes how the body uses energy reserves by lowering the respiratory exchange ratio (RER), a measure of which type of fuel the body is burning

29 Patients with DM suffer from oxidative stress 30, 31, 32 and hypertensive patients have been recognized to experience hyper-oxidative stress

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Moreover, a before/after implementation study of adolescents found greater fear of the consequences of smoking, and perception of less acceptability of smoking by family and friends 15