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Such reactions can range from responses with no clinical manifestations to irritating rashes to life-threatening conditions such as anaphylactic shock, which constricts breathing and impairs motor function

Recommended treatments also often must be tailored according to skin tone

Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020

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